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This proposal doesnt change access for patients using an FDA-approved GLP-1 Ozempic, Wegovy, Rybelsus, Mounjaro, Zepbound, Saxenda or Victoza

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Trained immunity exerts long-lasting effects on cell function through epigenetic regulation and metabolic reprogramming ( Table 1 ) and shows bidirectional roles in immune regulation: disease-induced trained immunity can, in turn, exacerbate pathology, creating a self-reinforcing vicious cycle

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